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§ 00 The Manual

Peptide therapy,
explained.

Peptides are short chains of amino acids — the body's own signaling molecules. In therapeutic use, they instruct cells to repair tissue, regulate hormones, reduce inflammation, and tune metabolic rhythm.

312
Clinical studies
47
Peptide profiles
EL1EL4
Evidence grading
§ 01 The Encyclopedia

The compounds
people ask
about most.

Each profile opens with status, mechanism, and a one-line summary so you can decide in seconds whether the rest is worth your reading time. The full record — dosing, half-life, and citation chain — unfolds below.

Browse all 47 profiles
Three amber peptide vials with white minimalist labels on cream linen

* Ranked by combined study volume, search demand, and clinician-flagged questions over the last 90 days.

No. 005
Trending FDA Approved

Semaglutide

Semaglutide

“The peptide that reshaped obesity medicine.”

Mechanism

GLP-1 receptor agonist — mimics the incretin hormone GLP-1 to slow gastric emptying, reduce appetite, and improve glycemic control via pancreatic beta-cell stimulation.

Class

Metabolic Health

Studies

5

No. 004
Trending FDA Approved

Tirzepatide

Tirzepatide

“Next-generation dual-receptor agonist rewriting weight loss benchmarks.”

Mechanism

Dual GIP/GLP-1 receptor agonist — simultaneously activates both incretin hormone receptors to produce additive metabolic effects exceeding GLP-1 agonism alone.

Class

Metabolic Health

Studies

4

No. 004
Trending Research Only

BPC-157

Body Protection Compound 157

“The body's own repair signal, amplified.”

Mechanism

Upregulates growth hormone receptor expression, promotes angiogenesis, and modulates nitric oxide synthesis in damaged tissue.

Class

Recovery

Studies

4

No. 004
Trending Research Only

TB-500

Thymosin Beta-4 Fragment

“Accelerated healing at the cellular level.”

Mechanism

Actin-sequestering peptide that promotes cell migration, angiogenesis, and anti-inflammatory signaling through Tβ4 receptor pathways.

Class

Recovery

Studies

4

Peptides don't promise more — they promise more precision. The body already speaks this language; we're just learning to listen for the verbs that matter.
— Peptidely · Editor's note
§ 03 Therapy Guides

Long-form, for the
curious clinician.

Featured guide
01 Getting Started 12 min read

The Complete Beginner's Guide to Peptide Therapy

Everything you need before your first protocol — how peptides work, what the research shows, how to evaluate a provider, and what questions to ask.

Read the guide
02 Metabolic Health

Peptides for Weight Loss: What the Evidence Actually Shows

An evidence-graded review of GLP-1 agonists, AOD-9604, and other metabolic peptides — separating marketing claims from peer-reviewed findings.

18 min read Open
03 Recovery

BPC-157: Mechanisms, Research Summary & Protocol Overview

The most comprehensive review of BPC-157 available — covering 48+ studies, proposed mechanisms, dosing considerations, and open research questions.

22 min read Open
A man reading the weekly research digest at a sunlit kitchen counter
§ 05 The Digest

Weekly briefings,
read in five minutes.

One email each Friday. New peptide approvals, landmark studies, protocol updates, and clinician-flagged questions — distilled into a single scannable digest.

4,200+
Subscribers
5 min
Read time
Stay current

The peptide
research digest.

Weekly briefings on new clinical studies, peptide approvals, protocol updates, and emerging research — curated for practitioners.

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